National Institute of Genetics, Mishima, 411-8540, Japan.
Genes (Basel). 2010 Sep 30;1(3):349-56. doi: 10.3390/genes1030349.
The importance of gene conversion for the evolution of gene families is reviewed. Four problems concerning gene conversion, i.e., concerted evolution, generation of useful variation, deleterious effects, and relation to neofunctionalization, are discussed by surveying reported examples of evolving gene families. Emphasis is given toward understanding interactive effects of gene conversion and natural selection.
本文回顾了基因转换在基因家族进化中的重要性。通过调查报道的进化基因家族的例子，讨论了基因转换的四个问题，即协同进化、有用变异的产生、有害影响以及与新功能化的关系。重点是理解基因转换和自然选择的相互作用效应。
