Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan.
Genes (Basel). 2011 Feb 22;2(1):219-28. doi: 10.3390/genes2010219.
Embryonic stem (ES) cells can differentiate into multiple types of cells belonging to all three germ layers. Although ES cells are clonally established, they display heterogeneous responses upon the induction of differentiation, resulting in a mixture of various types of differentiated cells. Our recent reports have shown that Hes1 regulates the fate choice of ES cells by repressing Notch signaling, and that the oscillatory expression of Hes1 contributes to various differentiation responses in ES cells. Here we discuss the mechanism regulating the intracellular dynamics in ES cells and how to trigger the lineage choice from pluripotent ES cells.
胚胎干细胞（ES 细胞）可分化为三个胚层所属的多种细胞类型。虽然 ES 细胞是通过克隆建立的，但在诱导分化时会表现出异质性反应，导致各种类型的分化细胞混合在一起。我们最近的研究报告表明，Hes1 通过抑制 Notch 信号通路来调节 ES 细胞的命运选择，并且 Hes1 的振荡表达有助于 ES 细胞的各种分化反应。在这里，我们讨论调节 ES 细胞内动力学的机制，以及如何从多能性 ES 细胞中触发谱系选择。
