Histological and pharmacological changes in vas deferens of rats exposed to hexachlorocyclohexane.

The effect of hexachlorocyclohexane (HCH) treatment in male albino rats at dosages of 3 and 6 mg/kg body weight by force-feeding were studied over a period of 180 days. Histological observations revealed graded degeneration in the muscular layer of vas deferens. Moreover, the accumulation of HCH residue in serum and vas deferens is highly significant in the experimental group. The contractility of muscles showed marked inhibition by in vitro study.