Kim Jee Hyun, Perry Christina, Luikinga Sophia, Zbukvic Isabel, Brown Robyn M, Lawrence Andrew J
Behavioural Neuroscience Division, The Florey Institute of Neuroscience and Mental Health, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Australia.
Addict Biol. 2015 May;20(3):482-9. doi: 10.1111/adb.12142. Epub 2014 Apr 9.
We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.
我们研究了消除动作-奖赏与情境-奖赏关联对药物引发的复吸的影响，以及代谢型谷氨酸5受体（mGlu5）在自行注射可卡因的大鼠的这些不同类型消退中的潜在作用。我们观察到，与被动戒断相比，每日情境消退（在杠杆缩回的情况下对可卡因使用情境进行无强化暴露）在减少可卡因引发的复吸方面与每日杠杆消退同样有效。此外，在每次消退训练后全身注射mGlu5负性变构调节剂MTEP（3-[(2-甲基-1,3-噻唑-4-基)乙炔基]-吡啶）显著损害了情境消退减少可卡因引发的复吸的能力，而不影响杠杆消退或被动戒断后的复吸。
