Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234.
作者信息
del Pino Javier, Ramos Eva, Aguilera Oscar M Bautista, Marco-Contelles José, Romero Alejandro
机构信息
Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
出版信息
CNS Neurosci Ther. 2014 Jun;20(6):568-70. doi: 10.1111/cns.12269. Epub 2014 Apr 8.
Abstract
摘要
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In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model.体内激活 Wnt 信号通路可增强成年小鼠的认知功能，并逆转阿尔茨海默病模型中的认知缺陷。
J Neurosci. 2014 Feb 5;34(6):2191-202. doi: 10.1523/JNEUROSCI.0862-13.2014.
2
Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.多功能、可渗透的药物 ASS234 抑制 Aβ 聚集，具有抗氧化特性，并能防止体外 Aβ 诱导的细胞凋亡。
Curr Alzheimer Res. 2013 Oct;10(8):797-808. doi: 10.2174/15672050113109990151.
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Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia.新型单胺氧化酶和胆碱酯酶靶向化合物对血管性痴呆大鼠模型脑神经递质和行为的影响。
Curr Pharm Des. 2014;20(2):161-71. doi: 10.2174/13816128113199990026.
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Wnt signaling: role in Alzheimer disease and schizophrenia.Wnt 信号通路：在阿尔茨海默病和精神分裂症中的作用。
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Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.多奈哌齐和 N-[(5-(苄氧基)-1-甲基-1H-吲哚-2-基)甲基]-N-甲基丙-2-炔-1-胺杂合体的合成、生物评价和分子模拟作为治疗阿尔茨海默病的新型多效胆碱酯酶/单胺氧化酶抑制剂。
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Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.过氧化物酶体增殖物激活受体 δ 通过转录激活抗氧化基因抑制血管平滑肌细胞中血管紧张素Ⅱ诱导的过早衰老。
Biochem Biophys Res Commun. 2011 Mar 25;406(4):564-9. doi: 10.1016/j.bbrc.2011.02.091. Epub 2011 Feb 23.
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Wnt signaling in neuroprotection and stem cell differentiation.Wnt信号通路在神经保护和干细胞分化中的作用
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The Wnt signaling pathway: aging gracefully as a protectionist?Wnt信号通路：作为一种保护机制而优雅地衰老？
Pharmacol Ther. 2008 Apr;118(1):58-81. doi: 10.1016/j.pharmthera.2008.01.004. Epub 2008 Feb 11.
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Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway.阿尔茨海默病中的乙酰胆碱酯酶（AChE）-β淀粉样肽复合物。Wnt信号通路。
Curr Alzheimer Res. 2004 Nov;1(4):249-54. doi: 10.2174/1567205043332063.
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Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss.乙酰胆碱酯酶 - β淀粉样蛋白复合物在大鼠海马体中比β淀粉样蛋白原纤维毒性更强：对大鼠β淀粉样蛋白聚集、层粘连蛋白表达、反应性星形胶质细胞增生和神经元细胞丢失的影响。
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