微小 RNA 在卵巢癌中的临床和诊断作用。
The clinical and diagnostic role of microRNAs in ovarian carcinoma.
机构信息
Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, N-0310 Oslo, Norway; University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, N-0310 Oslo, Norway.
University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, N-0310 Oslo, Norway; Department of Gynecologic Oncology, Oslo University Hospital, Norwegian Radium Hospital, N-0310 Oslo, Norway.
出版信息
Gynecol Oncol. 2014 Jun;133(3):640-6. doi: 10.1016/j.ygyno.2014.03.575. Epub 2014 Apr 5.
OBJECTIVE
MicroRNAs (miRNAs, miRs) are non-coding RNAs which post-transcriptionally regulate mRNA synthesis. Data regarding the expression and clinical relevance of miRNAs and the miRNA-regulating machinery in ovarian carcinoma has been rapidly expanding in recent years. This review presents current knowledge in this area.
METHODS
PubMed search was undertaken using the terms 'ovarian' and 'microRNA'.
RESULTS
A total of 492 papers were identified, of which approximately 100 were publications in English focusing exclusively or partly on clinical ovarian carcinoma specimens. These studies have identified multiple miRNAs with a potential role in the diagnosis, biology and progression of ovarian carcinoma, as well as on predicting chemoresponse and determining prognosis.
CONCLUSIONS
The presented data support a clinical role for miRNAs in ovarian carcinoma and suggest that miRNA-regulated pathways may be of relevance for novel therapeutics. Novel technologies offer new possibilities for wide-scale miRNA-based classification of OC. Further genomic research focusing on larger series of tumors of similar histological type in combination with experimental approaches is likely to expand our understanding of the role of miRNAs in this cancer.
目的
microRNAs（miRNAs，miRs）是一种非编码 RNA，可在后转录水平调节 mRNA 的合成。近年来，有关卵巢癌中 miRNAs 及其 miRNA 调控机制的表达和临床相关性的数据迅速增加。本综述介绍了该领域的最新知识。
方法
使用术语“卵巢”和“microRNA”在 PubMed 上进行搜索。
结果
共确定了 492 篇论文，其中约有 100 篇是英文出版物，专门或部分关注临床卵巢癌标本。这些研究已经确定了多种 miRNA，它们可能在卵巢癌的诊断、生物学和进展中具有潜在作用，并且可以预测化疗反应和确定预后。
结论
目前的数据支持 miRNA 在卵巢癌中的临床作用，并表明 miRNA 调控的途径可能与新型治疗方法有关。新技术为基于 miRNA 的 OC 大规模分类提供了新的可能性。进一步聚焦于具有相似组织学类型的大型肿瘤系列的基因组研究，结合实验方法，可能会扩大我们对 miRNA 在这种癌症中的作用的理解。
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