肺外部位转移性腺样囊性癌中甲状腺转录因子 1 和 napsin A 的异常表达。

Unusual expression of thyroid transcription factor 1 and napsin A in metastatic adenoid cystic carcinoma of extrapulmonary origin in the lung.

机构信息

Dept of Pathology, Ewha Womans University School of Medicine, 911-1 Mok-dong, Yangcheon-gu, Seoul, 158-710, Republic of Korea;

出版信息

Am J Clin Pathol. 2014 May;141(5):712-7. doi: 10.1309/AJCPB0YIY6LQLQTG.

DOI:10.1309/AJCPB0YIY6LQLQTG

PMID:24713744

Abstract

OBJECTIVES

Our study examines thyroid transcription factor 1 (TTF-1) expression in 40 primary adenoid cystic carcinomas (ACCs) arising in various sites and compares TTF-1 expression between primary and metastatic ACCs in 12 cases with distant metastases.

METHODS

Forty patients with ACCs, including 12 pairs of primary and metastatic ACCs, were evaluated for the immunohistochemical expression of TTF-1 (clone SPT24). In addition, 10 metastatic ACCs to the lung were tested on napsin A and a different TTF-1 antibody (clone 8G7G3) for further evaluation.

RESULTS

No primary ACCs showed TTF-1 immunoreactivity (clone SPT24). TTF-1 was positive in five (41.7%) of 12 metastatic ACCs; all five cases were found only in the lung and comprised five (50.0%) of 10 cases. In all positive cases, staining was focal and detected only in the cribriform histologic subtype. Staining patterns using both antibodies (both SPT24 and 8G7G3) were very similar, and TTF-1-positive tumor cells were also positive for napsin A. Extrapulmonary ACCs were all negative for TTF-1 regardless of origination and metastasis.

CONCLUSIONS

TTF-1- and napsin A-positive ACCs in the lung should not be considered primary ACCs because TTF-1 and napsin A can be expressed in metastatic ACCs of the lung.

摘要

目的

本研究检测了甲状腺转录因子 1（TTF-1）在 40 例发生于不同部位的原发性腺样囊性癌（ACC）中的表达，并比较了 12 例有远处转移的 ACC 中原发性和转移性 ACC 之间的 TTF-1 表达。

方法

评估了 40 例 ACC 患者（包括 12 对原发性和转移性 ACC）的 TTF-1（克隆 SPT24）免疫组化表达。此外，对 10 例转移性肺 ACC 进行了 napsin A 和另一种 TTF-1 抗体（克隆 8G7G3）的检测，以进一步评估。

结果

没有原发性 ACC 显示 TTF-1 免疫反应性（克隆 SPT24）。在 12 例转移性 ACC 中有 5 例（41.7%）为 TTF-1 阳性；这 5 例均仅在肺部发现，占 10 例中的 5 例。在所有阳性病例中，染色为局灶性，仅在筛状组织学亚型中检测到。两种抗体（SPT24 和 8G7G3）的染色模式非常相似，TTF-1 阳性的肿瘤细胞也对 napsin A 呈阳性。无论起源和转移如何，肺外 ACC 均为 TTF-1 阴性。