Svartholm E, Bergqvist D, Hedner U, Ljungberg J, Haglund U
Department of Surgery, Lund University, Malmö, Sweden.
Arch Surg. 1989 Jun;124(6):669-72. doi: 10.1001/archsurg.1989.01410060031006.
Septic shock was induced by intravenous infusion of live Escherichia coli in pigs to investigate the influences on central hemodynamic, coagulation, and fibrinolytic reactions by a thromboxane A2 (TxA2)-receptor blocker (BM 13.177; n = 6) and a prostacyclin analogue (iloprost or ZK 36,374; n = 7). The early pulmonary vasoconstriction following E coli infusion was attenuated, but not abolished, by BM 13.177. Only minor effects were seen after pretreatment with iloprost. Neither drug had any major effect on the coagulation and fibrinolytic activation. These results confirm that TxA2 is an important, but not the only, mediator of early pulmonary vascular response in porcine septicemia and that neither TxA2 nor prostacyclin is of major importance for the hemostatic reactions in this shock model.
通过给猪静脉注射活的大肠杆菌诱导脓毒性休克，以研究血栓素A2（TxA2）受体阻滞剂（BM 13.177；n = 6）和前列环素类似物（依洛前列素或ZK 36,374；n = 7）对中心血流动力学、凝血和纤溶反应的影响。BM 13.177可减轻但不能消除大肠杆菌注入后早期的肺血管收缩。依洛前列素预处理后仅见轻微效果。两种药物对凝血和纤溶激活均无重大影响。这些结果证实，TxA2是猪败血症早期肺血管反应的重要介质，但不是唯一介质，并且在该休克模型中，TxA2和前列环素对止血反应均不重要。
