POEMS综合征患者的复发性短暂性脑缺血发作
Recurrent Transient Ischemic Attacks in a Patient with POEMS Syndrome.
作者信息
Akyol A, Nazliel B, Batur Caglayan H Z, Oner Y, Sucak G Turkoz
机构信息
Department of Neurology, Faculty of Medicine, Gazi University, 06500 Ankara, Turkey.
Department of Radiology, Faculty of Medicine, Gazi University, 06500 Ankara, Turkey.
出版信息
Case Rep Neurol Med. 2014;2014:158471. doi: 10.1155/2014/158471. Epub 2014 Mar 4.
A 47-year-old female with a prior history of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome was admitted with transient ischemic attacks complicated by dysarthria and right-sided hemiparesis. A blood survey indicated thrombocytosis and hyperfibrinogenemia while imaging of intracranial vasculature showed occlusion of the bilateral middle cerebral arteries. POEMS syndrome, of which arterial thromboses have been mentioned as a manifestation, is rarely accompanied by transient ischemic attacks. The pathophysiologic mechanism is yet unclear and needs further investigation.
一名47岁女性，既往有POEMS（多发性神经病、器官肿大、内分泌病、单克隆丙种球蛋白病和皮肤改变）综合征病史，因短暂性脑缺血发作入院，并发构音障碍和右侧偏瘫。血液检查显示血小板增多和纤维蛋白原血症升高，而颅内血管成像显示双侧大脑中动脉闭塞。POEMS综合征虽有动脉血栓形成作为其一种表现的相关报道，但很少伴有短暂性脑缺血发作。其病理生理机制尚不清楚，需要进一步研究。
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