濑户小鼠中枢神经系统中儿茶酚胺和吲哚胺的浓度。

Concentrations of catecholamines and indoleamines in the central nervous system of Wriggle mouse Sagami.

Kumazawa T, Adachi K, Ando K

National Institute of Neuroscience, Tokyo, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;93(1):167-9. doi: 10.1016/0742-8413(89)90028-5.

Abstract

The concentrations of norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the central nervous system of Wriggle mouse Sagami (WMS), which is a new ataxic mutant mouse, were studied. 2. NE and MHPG levels were increased most remarkably in the cerebellum. 3. 5-HT and 5-HIAA levels were increased most remarkably in the brain stem and spinal cord. 4. The present results suggest enhancement of catecholamine and indoleamine metabolism in the cerebellum and bulbospinal cord, respectively, of the WMS, and these changes seem relevant to the specific motor dysfunction of the WMS.

摘要

对一种新的共济失调突变小鼠——相模摆动小鼠（WMS）中枢神经系统中去甲肾上腺素（NE）、3-甲氧基-4-羟基苯乙二醇（MHPG）、5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的浓度进行了研究。2. 小脑内NE和MHPG水平升高最为显著。3. 脑干和脊髓中5-HT和5-HIAA水平升高最为显著。4. 目前的结果表明，WMS的小脑和延髓脊髓中儿茶酚胺和吲哚胺代谢分别增强，这些变化似乎与WMS的特定运动功能障碍有关。