Morphometric analysis on the effects of hypoxia during the central nervous system vasculogenesis.

A morphometric analysis was carried out on the optic tectum microvascolature in chicken embryos developing under normal and hypoxic conditions in order to evaluate the effects of an environmental O2 reduction on growing neural blood vessels. The vessel number, the vessel diameter and the distance intervening between contiguous vessels were measured. In the developing tectum under hypoxia the results evidenced a remarkable, progressive increase in vessel number, higher than in the controls; a transitory increment of the vessel diameter, which in later embryonic development returned similar to that recorded during normal tectum vasculogenesis; a value of the distance between contiguous vessels always much lower than under normal conditions. The possible significances of these morphological evidences were discussed and a capacity on the part of the growing neural vascular bed for adapting itself to a reduced oxygen concentration was noted.