Roncali L, Ribatti D, Ambrosi G
J Submicrosc Cytol. 1985 Jan;17(1):83-8.
The mode and the temporal sequence of the growth and differentiation processes of the intraneural blood vessels have been ultrastructurally analyzed in optic tecta of 4, 8, 12, 16 and 19 incubation day chick embryos and of chicks 15 days after hatching. The findings suggest that the morphological maturation of the various components of the vascular wall and perivascular spaces, leading to the formation of the blood-brain barrier, unfold according to a spatio-temporal gradient, radially extending from the surface of the tectum rudiment.
对孵化4天、8天、12天、16天和19天的鸡胚以及孵化后15天的雏鸡视顶盖内神经血管生长和分化过程的模式及时间顺序进行了超微结构分析。研究结果表明，血管壁和血管周围间隙各成分的形态成熟，导致血脑屏障的形成，是按照从顶盖原基表面呈放射状延伸的时空梯度展开的。
