Kalapatapu Raj K, Neylan Thomas C, Regan Mathilda C, Cohen Beth E
a Department of Psychiatry , University of California , San Francisco , California , USA.
J Addict Dis. 2014;33(2):67-76. doi: 10.1080/10550887.2014.909701.
The authors conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., aspartate aminotransferase) may have a specific role in identifying veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance.
作者对85名有酒精使用问题和创伤后应激障碍（PTSD）的退伍军人进行了一项关于酒精使用生物标志物与认知表现的研究。所有分析都针对人口统计学因素、抑郁、焦虑和PTSD症状进行了调整。天冬氨酸转氨酶水平升高与连线测验A部分和霍普金斯词语学习测验的较差表现相关。其他两种生物标志物与任何神经认知指标均无关联。间接酒精使用生物标志物（如天冬氨酸转氨酶）可能在识别有酒精使用问题和PTSD且表现出心理运动速度和即时言语记忆表现变化的退伍军人方面具有特定作用。
