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铁、锰和镍的三聚硫氰酸酯配合物及其抗胆碱酯酶活性。

Trithiocyanurate complexes of iron, manganese and nickel and their anticholinesterase activity.

作者信息

Kopel Pavel, Dolezal Karel, Langer Vratislav, Jun Daniel, Adam Vojtech, Kuca Kamil, Kizek Rene

机构信息

Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.

Centre of the Region Hana for Biotechnological and Agricultural Research, Faculty of Science, Palacky University & Institute of Experimental Botany, Academy of Sciences of Czech Republic, Slechtitelu 11, CZ-783 71 Olomouc, Czech Republic.

出版信息

Molecules. 2014 Apr 8;19(4):4338-54. doi: 10.3390/molecules19044338.

DOI:10.3390/molecules19044338
PMID:24717551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6272027/
Abstract

The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition Fe(L1)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.

摘要

制备了铁（II）、锰（II）和镍（II）与席夫碱、氮供体配体或大环配体以及三硫氰尿酸（ttcH3）组合而成的配合物，并通过元素分析和光谱学对其进行了表征。解析了组成为Fe(L1)(ClO4)·EtOH·H2O（1）的铁配合物的晶体和分子结构，其中L1是由三（2-氨基乙基）胺和2-吡啶甲醛衍生的席夫碱。结果发现，席夫碱通过六个氮原子与中心铁原子配位，形成变形八面体排列，而硫氰尿酸根（1-）阴离子、高氯酸根和溶剂分子未配位。还给出了席夫碱钠盐的X射线结构，并与铁配合物进行了比较。此外，还研究了这些配合物的抗胆碱酯酶活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/69f604b560cc/molecules-19-04338-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/b011b1f42f52/molecules-19-04338-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/7780c85cfcad/molecules-19-04338-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/e77c653dbf84/molecules-19-04338-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/6a63a082de99/molecules-19-04338-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/e58a217cdb18/molecules-19-04338-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/daf26de86081/molecules-19-04338-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/69f604b560cc/molecules-19-04338-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/b011b1f42f52/molecules-19-04338-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/7780c85cfcad/molecules-19-04338-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/e77c653dbf84/molecules-19-04338-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/6a63a082de99/molecules-19-04338-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/e58a217cdb18/molecules-19-04338-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/daf26de86081/molecules-19-04338-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d7a/6272027/69f604b560cc/molecules-19-04338-g007.jpg

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