Pignatti Emanuele, Zeller Rolf, Zuniga Aimée
Developmental Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
Developmental Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
Semin Cell Dev Biol. 2014 Aug;32:119-27. doi: 10.1016/j.semcdb.2014.04.004. Epub 2014 Apr 6.
The analysis of vertebrate limb bud development provides insight of general relevance into the signaling networks that underlie the controlled proliferative expansion of large populations of mesenchymal progenitors, cell fate determination and initiation of differentiation. In particular, extensive genetic analysis of mouse and experimental manipulation of chicken limb bud development has revealed the self-regulatory feedback signaling systems that interlink the main morphoregulatory signaling pathways including BMPs and their antagonists. It this review, we showcase the key role of BMPs and their antagonists during limb bud development. This review provides an understanding of the key morphoregulatory interactions that underlie the highly dynamic changes in BMP activity and signal transduction as limb bud development progresses from initiation and setting-up the signaling centers to determination and formation of the chondrogenic primordia for the limb skeletal elements.
对脊椎动物肢体芽发育的分析，为深入了解间充质祖细胞大量受控增殖性扩张、细胞命运决定及分化起始所依赖的信号网络提供了具有普遍意义的见解。特别是，对小鼠的广泛遗传学分析以及对鸡肢体芽发育的实验操作，揭示了相互连接包括骨形态发生蛋白（BMPs）及其拮抗剂在内的主要形态调节信号通路的自我调节反馈信号系统。在本综述中，我们展示了BMPs及其拮抗剂在肢体芽发育过程中的关键作用。本综述有助于理解随着肢体芽发育从信号中心的起始与建立，进展到肢体骨骼元件软骨原基的决定与形成，BMP活性和信号转导发生高度动态变化所依据的关键形态调节相互作用。
