Iyoda Akira, Makino Takashi, Koezuka Satoshi, Otsuka Hajime, Hata Yoshinobu
Division of Chest Surgery, Department of Surgery, School of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan,
Gen Thorac Cardiovasc Surg. 2014 Jun;62(6):351-6. doi: 10.1007/s11748-014-0379-9. Epub 2014 Apr 10.
Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a variant of large cell carcinomas, and LCNEC tumors display biological behaviors resembling those of small cell lung carcinomas and features of high-grade neuroendocrine tumors. Because patients with LCNEC have a poor prognosis, surgery alone is not sufficient. Multimodality therapies, including adjuvant chemotherapy, appear promising for improved prognosis in patients with LCNEC. In this review article, we discuss treatment options for patients with LCNEC of the lung.
肺大细胞神经内分泌癌（LCNEC）被归类为大细胞癌的一种变体，LCNEC肿瘤表现出类似于小细胞肺癌的生物学行为以及高级别神经内分泌肿瘤的特征。由于LCNEC患者预后较差，单纯手术并不足够。包括辅助化疗在内的多模式治疗对于改善LCNEC患者的预后似乎很有前景。在这篇综述文章中，我们讨论了肺LCNEC患者的治疗选择。
