对于伴有不可切除转移灶的IV期结直肠癌患者，切除原发灶是否能带来生存获益？

Does resection of primary lesions show survival benefit for stage IV colorectal cancer patients with unresectable metastases?

作者信息

Ichikawa Yasushi, Goto Ayumu, Kobayashi Noritoshi, Ota Mitsuyoshi, Tokuhisa Motohiko, Ishibez Atsushi, Watanabe Jun, Watanabe Kazuteru, Ishikawa Takashi, Tanaka Kuniya, Akiyama Hirotoshi, Fujii Shoichi, Endo Itaru

出版信息

Hepatogastroenterology. 2013 Nov-Dec;60(128):1945-9.

PMID:24719932

Abstract

BACKGROUND/AIMS: The aims of the current retrospective cohort study were to compare OS of the primary resection (R-g) and the non-resection group (NR-g) after 2005.

METHODOLOGY

Ninety-five patients with stage IV colorectal cancer with unresectable distant metastases were divided into 2 groups; R-g; 37 and NR-g; 58.

RESULTS

The only significant difference in clinical factors between the 2 was R0 resection rate (p = 0.007). The MST in R-g was superior to that in NR-g, 30.7 vs. 21.9 months (p = 0.031). After excluding the patients that underwent R0 resection, there was no difference in OS between the 2; however, the MST was 28.6 months in R-g and 17.1 months in NR-g.

CONCLUSIONS

The advantage of resection of the primary is still unclear and a well-designed randomized Phase III study is expected. However, the current results suggest that resection of the primary lesion before intensive chemotherapy had some benefit for prognosis.

摘要

背景/目的：本回顾性队列研究的目的是比较2005年后原发性切除组（R-g）和非切除组（NR-g）的总生存期（OS）。