Strach Magdalena, Nalepa Piotr, Sulicka-Grodzicka Joanna, Kierzkowska Izabella, Siedlar Maciej, Grodzicki Tomasz
Przegl Lek. 2013;70(12):1058-60.
Mycobacteria is a large group of pathogens that are common in environment, in soil and tap water. Although mycobacteria [non tuberculosis mycobacteria] can inhabit body surface without causing any disease in the circumstances of primary or secondary immunodeficiency can cause clinically significant organ or systemic damage. Defect of IL-12/INFgamma axis is an example of primary immunodeficiency that predispose to mycobacterial infections while protection against other microorganisms is not damaged. We present review of known defects of IL-12/IFNgamma axis and brief presentation of our own experience.
分枝杆菌是一大类病原体，在环境中很常见，存在于土壤和自来水中。虽然分枝杆菌（非结核分枝杆菌）可寄居于体表，在原发性或继发性免疫缺陷情况下不会引起任何疾病，但却可导致具有临床意义的器官或全身损害。IL-12/INFγ轴缺陷是原发性免疫缺陷的一个例子，它易引发分枝杆菌感染，而对其他微生物的防御功能并未受损。我们对已知的IL-12/IFNγ轴缺陷进行综述，并简要介绍我们自己的经验。
