Weyand C M, Goronzy J, Swarztrauber K, Fathman C G
Department of Medicine, Heidelberg University Medical School, Federal Republic of Germany.
Transplantation. 1989 Jun;47(6):1039-42. doi: 10.1097/00007890-198906000-00024.
Antibody-mediated elimination of CD4+ lymphocytes in vivo has been successfully used to suppress the humoral response to foreign antigens and to induce long-term tolerance. However, secondary humoral responses, as well as secondary cytolytic responses specific for viral antigens, could not be prevented, providing evidence for functional heterogeneity within the helper cell compartment. Data presented here support the notion that helper cell requirements for cellular responses to alloantigens are unique and do not involve CD4+ T lymphocytes. While the administration of anti-CD4 mcAb failed to suppress allospecific CTL responses, the formation of alloantibodies was initially inhibited in parallel to the deficiency in CD4+ helper cells. After regeneration of CD4+ T cells, the animals regained the ability to produce specific IgG alloantibodies. The dichotomy of helper pathways in humoral and cellular alloreactive responses challenges the concept of a single CD4+ helper cell population. Insights into the functional heterogeneity of helper cells for primary, secondary, and allospecific responses might open new avenues for selective manipulation of helper subpopulations.
体内抗体介导的CD4+淋巴细胞清除已成功用于抑制对外源抗原的体液反应并诱导长期耐受。然而，无法预防二次体液反应以及针对病毒抗原的二次细胞溶解反应，这为辅助细胞区室内的功能异质性提供了证据。此处呈现的数据支持以下观点，即辅助细胞对同种异体抗原的细胞反应需求是独特的，且不涉及CD4+ T淋巴细胞。虽然抗CD4单克隆抗体的施用未能抑制同种异体特异性CTL反应，但同种异体抗体的形成最初与CD4+辅助细胞的缺乏同时受到抑制。CD4+ T细胞再生后，动物恢复了产生特异性IgG同种异体抗体的能力。体液和细胞同种异体反应中辅助途径的二分法挑战了单一CD4+辅助细胞群体的概念。对初次、二次和同种异体特异性反应的辅助细胞功能异质性的深入了解可能为辅助亚群的选择性操纵开辟新途径。
