Universite du Droit et de la Sante de Lille, EA 4481, Institut de Chimie Pharmaceutique Albert Lespagnol, 3 rue du Pr. Laguesse, B.P. 83, F-59006 Lille, France.
Curr Mol Pharmacol. 2013 Nov;6(3):183-203. doi: 10.2174/1874467207666140219122337.
The cannabinoid receptor CB2 is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB2 is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver disease and osteoporosis. This article reviews the CB2 involvement in the immune system and the promising therapeutical potential of selective CB2 agonists in the treatment of several immune-related diseases.
大麻素受体 CB2 在免疫细胞中高度表达，提示其在许多疾病中具有重要作用，如炎症、癌症、骨质疏松症和与免疫系统调节有关的肝病。因此，激活受体 CB2 是治疗多种疾病的一种很有前途的治疗策略。事实上，选择性 CB2 激动剂具有有益的抗炎、抗癌和抗纤维化特性，并对肝病和骨质疏松症有积极影响。本文综述了 CB2 在免疫系统中的作用以及选择性 CB2 激动剂在治疗几种与免疫相关的疾病中的潜在治疗作用。
