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Discovery, synthesis, and structure-activity relationships of conotoxins.

作者信息

Akondi Kalyana B, Muttenthaler Markus, Dutertre Sébastien, Kaas Quentin, Craik David J, Lewis Richard J, Alewood Paul F

机构信息

Institute for Molecular Bioscience, The University of Queensland , Brisbane, Queensland 4072, Australia.

出版信息

Chem Rev. 2014 Jun 11;114(11):5815-47. doi: 10.1021/cr400401e. Epub 2014 Apr 10.

DOI:10.1021/cr400401e
PMID:24720541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7610532/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8da6c292ea98/EMS120706-f017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/24a012cd5eb6/EMS120706-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/6a84c350012c/EMS120706-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/f3955a074ff4/EMS120706-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/10e81be87cfd/EMS120706-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/be4d686c2726/EMS120706-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/2376ec543713/EMS120706-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/d21004e18fec/EMS120706-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/356bcca7cb80/EMS120706-f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/db6926d3ff9c/EMS120706-f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/e756a4f395f7/EMS120706-f010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/9d0407c68810/EMS120706-f011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/d680c48627a2/EMS120706-f012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8a7c2de00430/EMS120706-f013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/f2ec4b02fd71/EMS120706-f014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/b24595b5c3ab/EMS120706-f015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8001b0b96c07/EMS120706-f016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8da6c292ea98/EMS120706-f017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/24a012cd5eb6/EMS120706-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/6a84c350012c/EMS120706-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/f3955a074ff4/EMS120706-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/10e81be87cfd/EMS120706-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/be4d686c2726/EMS120706-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/2376ec543713/EMS120706-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/d21004e18fec/EMS120706-f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/356bcca7cb80/EMS120706-f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/db6926d3ff9c/EMS120706-f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/e756a4f395f7/EMS120706-f010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/9d0407c68810/EMS120706-f011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/d680c48627a2/EMS120706-f012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8a7c2de00430/EMS120706-f013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/f2ec4b02fd71/EMS120706-f014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/b24595b5c3ab/EMS120706-f015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8001b0b96c07/EMS120706-f016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/7610532/8da6c292ea98/EMS120706-f017.jpg

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本文引用的文献

1
ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels.ω-芋螺毒素 GVIA 类似物，能结合并抑制神经元 Ca(v)2.2 离子通道。
Mar Drugs. 2012 Oct;10(10):2349-2368. doi: 10.3390/md10102349. Epub 2012 Oct 22.
2
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.深静脉组学揭示了芋螺毒液中肽多样性扩展的机制。
Mol Cell Proteomics. 2013 Feb;12(2):312-29. doi: 10.1074/mcp.M112.021469. Epub 2012 Nov 14.
3
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.钠离子通道 β 亚基的共表达改变了孔阻断型 μ-芋螺毒素对电压门控钠离子通道的抑制动力学。
Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.
4
IUPHAR-DB: updated database content and new features.IUPHAR-DB：更新数据库内容和新功能。
Nucleic Acids Res. 2013 Jan;41(Database issue):D1083-8. doi: 10.1093/nar/gks960. Epub 2012 Oct 18.
5
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.通过在芋螺毒液腺中的多酶复合物，实现芋螺毒素结构和功能的调节。
J Biol Chem. 2012 Oct 5;287(41):34288-303. doi: 10.1074/jbc.M112.366781. Epub 2012 Aug 13.
6
Therapeutic potential of cone snail venom peptides (conopeptides).芋螺毒素肽（conopeptides）的治疗潜力。
Curr Top Med Chem. 2012;12(14):1546-52. doi: 10.2174/156802612802652457.
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Mol Pharmacol. 2012 Oct;82(4):711-8. doi: 10.1124/mol.112.078683. Epub 2012 Jul 16.
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Molecular phylogeny, classification and evolution of conopeptides.缩氨酸的分子系统发生、分类与进化。
J Mol Evol. 2012 Jun;74(5-6):297-309. doi: 10.1007/s00239-012-9507-2. Epub 2012 Jul 4.
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Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct.通过 Cone snail Conus geographus 毒腺转录组测序阐明其分子中毒策略。
BMC Genomics. 2012 Jun 28;13:284. doi: 10.1186/1471-2164-13-284.