Roy A, De Jong J, Linnoila M
Division of Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md 20892.
Arch Gen Psychiatry. 1989 Jul;46(7):609-12. doi: 10.1001/archpsyc.1989.01810070035005.
We carried out a 5-year follow-up study of suicidal behavior among depressed patients who earlier had determinations of cerebrospinal fluid levels of monoamine metabolites. Patients who reattempted suicide during the follow-up had significantly lower cerebrospinal fluid levels of both the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid. The findings were most striking among melancholic patients. These follow-up results suggest that reduced central turnover of serotonin and dopamine may be associated with further suicidal behavior among depressed patients who have previously attempted suicide.
我们对早期测定过脑脊液中单胺代谢物水平的抑郁症患者的自杀行为进行了一项为期5年的随访研究。在随访期间再次尝试自杀的患者，其脑脊液中血清素代谢物5-羟吲哚乙酸和多巴胺代谢物高香草酸的水平显著较低。这些发现以忧郁症患者中最为显著。这些随访结果表明，血清素和多巴胺的中枢周转率降低可能与之前有过自杀未遂经历的抑郁症患者的进一步自杀行为有关。
