Kakoki Katsura, Kamiyama Haruka, Izumida Mai, Yashima Yuka, Hayashi Hideki, Yamamoto Naoki, Matsuyama Toshifumi, Igawa Tsukasa, Sakai Hideki, Kubo Yoshinao
Division of Cytokine Signaling, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan; Department of AIDS Research, Institute of Tropical Medicine, G-COE, Nagasaki University, Nagasaki 852-8523, Japan; Department of Urology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Division of Cytokine Signaling, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan; Department of AIDS Research, Institute of Tropical Medicine, G-COE, Nagasaki University, Nagasaki 852-8523, Japan.
Biochem Biophys Res Commun. 2014 Apr 25;447(1):216-22. doi: 10.1016/j.bbrc.2014.03.154. Epub 2014 Apr 8.
Xenotropic murine leukemia virus-related virus (XMRV) is a novel gammaretrovirus that was originally isolated from human prostate cancer. It is now believed that XMRV is not the etiologic agent of prostate cancer. An analysis of murine leukemia virus (MLV) infection in various human cell lines revealed that prostate cancer cell lines are preferentially infected by XMRV, and this suggested that XMRV infection may confer some sort of growth advantage to prostate cancer cell lines. To examine this hypothesis, androgen-dependent LNCaP cells were infected with XMRV and tested for changes in certain cell growth properties. We found that XMRV-infected LNCaP cells can proliferate in the absence of the androgen dihydrotestosterone. Moreover, androgen receptor expression is significantly reduced in XMRV-infected LNCaP cells. Such alterations were not observed in uninfected and amphotropic MLV-infected LNCaP cells. This finding explains why prostate cancer cell lines are preferentially infected with XMRV.
异嗜性小鼠白血病病毒相关病毒（XMRV）是一种新型γ逆转录病毒，最初从人类前列腺癌中分离出来。现在认为XMRV不是前列腺癌的病原体。对各种人类细胞系中的小鼠白血病病毒（MLV）感染进行的分析表明，前列腺癌细胞系优先被XMRV感染，这表明XMRV感染可能赋予前列腺癌细胞系某种生长优势。为了检验这一假设，用XMRV感染雄激素依赖性LNCaP细胞，并检测某些细胞生长特性的变化。我们发现，感染XMRV的LNCaP细胞可以在没有雄激素双氢睾酮的情况下增殖。此外，感染XMRV的LNCaP细胞中雄激素受体表达显著降低。在未感染和感染嗜异性MLV的LNCaP细胞中未观察到这种改变。这一发现解释了为什么前列腺癌细胞系优先被XMRV感染。
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