出血性休克院前处理中的静脉输液治疗：在猪模型中使用高渗盐水/6%右旋糖酐70可改善预后

Intravenous fluid therapy in the prehospital management of hemorrhagic shock: improved outcome with hypertonic saline/6% Dextran 70 in a swine model.

作者信息

Chudnofsky C R, Dronen S C, Syverud S A, Zink B J, Hedges J R

机构信息

Department of Emergency Medicine, University of Cincinnati College of Medicine.

出版信息

Am J Emerg Med. 1989 Jul;7(4):357-63. doi: 10.1016/0735-6757(89)90038-7.

DOI:10.1016/0735-6757(89)90038-7

PMID:2472149

Abstract

The small quantities of 7.5% hypertonic saline (HTS) in 6% Dextran 70 (DEX 70; Travenol Laboratories, Deerfield, IL) required to produce marked improvement in tissue perfusion may make it an ideal solution for the prehospital management of hypotensive trauma patients. This study shows that the initial treatment of porcine hemorrhagic shock with 7.5% HTS/6% DEX 70 results in significantly improved hemodynamics and higher survival rates than those seen in animals treated with normal saline. These results are very encouraging and dictate the need for evaluation in human trials.

摘要

在6%右旋糖酐70（DEX 70；特拉文诺尔实验室，伊利诺伊州迪尔菲尔德）中加入少量7.5%高渗盐水（HTS）就能显著改善组织灌注，这使其可能成为院前低血压创伤患者治疗的理想溶液。本研究表明，用7.5% HTS/6% DEX 70对猪失血性休克进行初始治疗，与用生理盐水治疗的动物相比，能显著改善血流动力学并提高生存率。这些结果非常令人鼓舞，表明有必要在人体试验中进行评估。