2nd Cardiology Department, "Hellenic Red Cross" Hospital of Athens, Greece.
Department of Endocrinology, Diabetes and Metabolism, "Evangelismos" General Hospital, Greece.
Hormones (Athens). 2014 Jan-Mar;13(1):79-86. doi: 10.1007/BF03401323.
This study surveyed the frequencies of single nucleotide polymorphisms (SNPs) M235T AGT and C825T GNB3, and their association with insulin resistance, other biochemical markers and qualitative variables in subjects with high normal blood pressure and/or prehypertension in the Greek population.
330 men and women of Greek origin were divided into 3 groups: a) hypertensive, b) prehypertensive and c) control group. These groups were genetically tested for these polymorphisms and insulin resistance with the HOMA index.
No statistically significant differences were found among the polymorphisms of the compared groups. However, the ? allele carriers (CT/TT vs. CC) of the C825T polymorphism were associated with an increased BMI in all 3 groups (p=0.004). The HOMA index was higher in the hypertensive (p=0.006) and prehypertensive (p=0.016) versus the control group, and similar results were found for insulin (hypertensive vs. control p=0.012, prehypertensive vs. control p=0.001) without statistical significance between the first 2 groups (p=0.522). Additionally, there was a statistically significant difference between the control group and the hypertensive and prehypertensive groups regarding cholesterol (control vs. hypertensive p=0.001, control vs. prehypertension p=0.018) and triglycerides (control vs. hypertensive p=0.0001, control vs. prehypertension p=0.007). Differences were also noted between the control and the hypertensive group regarding the value of HDL (p=0.005) and LDL (p=0.013).
This study failed to demonstrate a correlation between specific SNPs, blood pressure and insulin resistance in the 3 groups. However, T allele carriers of the polymorphism C825T were found to have an increased BMI. Similarly, increased insulin resistance and lipidemia were more common in the hypertensive and prehypertensive populations.
本研究调查了单核苷酸多态性（SNP）M235T AGT 和 C825T GNB3 的频率，以及它们与希腊人群中血压正常偏高和/或高血压前期患者的胰岛素抵抗、其他生化标志物和定性变量的相关性。
330 名希腊裔男女分为 3 组：a）高血压组，b）高血压前期组，c）对照组。这些组接受了这些多态性和胰岛素抵抗的基因检测，使用 HOMA 指数。
比较组之间的多态性无统计学差异。然而，C825T 多态性的 C 等位基因携带者（CT/TT 与 CC）在所有 3 组中与 BMI 增加相关（p=0.004）。高血压组（p=0.006）和高血压前期组（p=0.016）的 HOMA 指数高于对照组，胰岛素也有类似结果（高血压与对照组相比，p=0.012；高血压前期与对照组相比，p=0.001），但前两组之间无统计学差异（p=0.522）。此外，在胆固醇方面，对照组与高血压组和高血压前期组之间存在统计学差异（对照组与高血压组，p=0.001；对照组与高血压前期组，p=0.018）和甘油三酯（对照组与高血压组，p=0.0001；对照组与高血压前期组，p=0.007）。在 HDL 值（p=0.005）和 LDL 值（p=0.013）方面，对照组与高血压组也存在差异。
本研究未能证明 3 组中特定 SNP、血压和胰岛素抵抗之间存在相关性。然而，C825T 多态性的 T 等位基因携带者发现 BMI 增加。同样，高血压和高血压前期人群中胰岛素抵抗和血脂异常更为常见。
