Watanabe Hideo, Brooks Angela N, Meyerson Matthew
*Department of Medical Oncology; †Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston; ‡Cancer Program, Broad Institute of Harvard and M.I.T., Cambridge; and §Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA.
J Thorac Oncol. 2014 May;9(5):590-2. doi: 10.1097/JTO.0000000000000168.
The work by Mizukami et al., published in this issue, describes precise genomic breakpoints on 18 lung adenocarcinoma samples with oncogenic rearrangements, which occur in ~2% of lung adenocarcinomas. Sequence analysis indicates that breakpoints occur at non-specific sites, using variable mechanisms for DNA repair. This study provides important information for the development of molecular tests for this genomic rearrangement.
水kami等人发表在本期的研究描述了18例具有致癌重排的肺腺癌样本中的精确基因组断点，这种情况约占肺腺癌的2%。序列分析表明，断点出现在非特异性位点，采用了可变的DNA修复机制。这项研究为针对这种基因组重排的分子检测开发提供了重要信息。
