多发性硬化的复发缓解和进展形式：病理学的见解。
Relapsing and progressive forms of multiple sclerosis: insights from pathology.
机构信息
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Curr Opin Neurol. 2014 Jun;27(3):271-8. doi: 10.1097/WCO.0000000000000094.
PURPOSE OF REVIEW
The predominant clinical disease course of multiple sclerosis starts with reversible episodes of neurological disability, which transforms into progressive neurological decline. This review provides insight into the pathological differences during relapsing and progressive phases of multiple sclerosis.
RECENT FINDINGS
The clinical course of multiple sclerosis is variable, and the disease can be classified into relapsing and progressive phases. Pathological studies have been successful in distinguishing between these two forms of the disease and correlate with the clinical findings in terms of cellular responses, the inflammatory environment, and the location of lesions.
SUMMARY
Available therapies for multiple sclerosis patients, while effective during the relapsing phase, have little benefit for progressive multiple sclerosis patients. Development of therapies to benefit progressive multiple sclerosis patients will require a better understanding of the pathogenesis of progressive multiple sclerosis. This review discusses and compares the pathological findings in relapsing and progressive multiple sclerosis patients.
目的综述
多发性硬化的主要临床病程始于神经功能障碍的可逆发作，然后转变为进行性神经功能下降。本综述深入探讨了多发性硬化复发和进展阶段的病理差异。
最近的发现
多发性硬化的临床病程是多变的，可分为复发型和进展型。病理学研究成功地区分了这两种疾病形式，并与细胞反应、炎症环境和病变部位的临床发现相关。
总结
多发性硬化患者的现有治疗方法在复发期有效，但对进展型多发性硬化患者益处不大。开发对进展型多发性硬化患者有益的治疗方法需要更好地了解进展型多发性硬化的发病机制。本综述讨论并比较了复发型和进展型多发性硬化患者的病理发现。
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