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空气如何影响多孔培养板中的辐射剂量沉积：辐射几何结构的蒙特卡罗模拟

How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry.

作者信息

Sabater Sebastia, Berenguer Roberto, Honrubia-Gomez Paloma, Rivera Miguel, Nuñez Ana, Jimenez-Jimenez Esther, Martos Ana, Ramirez-Castillejo Carmen

机构信息

Department of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain

Department of Medical Physics, Complejo Hospitalario Universitario de Albacete (CHUA), C/ Hnos Falcó 37, 02006 Albacete, Spain.

出版信息

J Radiat Res. 2014 Sep;55(5):1009-14. doi: 10.1093/jrr/rru022. Epub 2014 Apr 10.

DOI:10.1093/jrr/rru022
PMID:24722683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4202281/
Abstract

Radiation of experimental culture cells on plates with various wells can cause a risk of underdosage as a result of the existence of multiple air-water interfaces. The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of ∼ 4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.

摘要

在具有不同孔的平板上对实验培养细胞进行辐射时，由于存在多个气 - 水界面，可能会导致剂量不足的风险。我们研究的目的是量化具有多个孔的培养板中的这种误差。基于GEANT4代码，使用GAMOS代码模拟辐射条件，并将其与使用PENELOPE进行的模拟以及测量数据进行比较。我们观察到培养基最表层的一半存在约4%的轻微剂量不足。我们认为这种剂量不足对单层沉积并附着在孔底部的培养细胞所接受的剂量没有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/a74df082d1d4/rru02205.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/282cd3e0e101/rru02201.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/b3fd3403ebf8/rru02202.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/4e8522c53a4f/rru02203.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/5f9083d153ac/rru02204.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/a74df082d1d4/rru02205.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/282cd3e0e101/rru02201.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/b3fd3403ebf8/rru02202.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/4e8522c53a4f/rru02203.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/5f9083d153ac/rru02204.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6955/4202281/a74df082d1d4/rru02205.jpg

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