中国汉族健康成年人血浆前胃泌素释放肽（ProGRP）水平的参考区间。
Reference intervals for plasma pro-gastrin releasing peptide (ProGRP) levels in healthy adults of Chinese Han ethnicity.
作者信息
Zhang Jie, Zhao Ying, Chen Yu
机构信息
Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou - China.
出版信息
Int J Biol Markers. 2014 Dec 9;29(4):e436-9. doi: 10.5301/jbm.5000084.
OBJECTIVES
To determine the upper limits of the 95th percentile reference intervals (RIs) for the detection of the pro-gastrin releasing peptide (ProGRP) in plasma according to the Clinical and Laboratory Standards Institute (CLSI) C28-A3 guideline in a population of adult Chinese of Han ethnicity.
METHODS
Plasma samples were collected from 578 healthy adults. Plasma ProGRP values were measured by chemiluminescent microparticle immunoassay (CMIA) on Abbot ARCHITECT i2000 system analyzers.
RESULTS
Plasma ProGRP values did not conform to a Gaussian distribution, and thus non-parametric statistical methods were used to calculate RIs. Plasma ProGRP levels significantly increased with age, thus age-dependent RIs were determined. The upper limit of the 95th percentile RIs for plasma ProGRP was ≤57.26 pg/mL for young adults (18-50 years) and ≤81.42 pg/mL for old adults (>50 years).
CONCLUSIONS
By CMIA, we established distinct age-dependent RIs for plasma ProGRP in healthy adults of Chinese Han ethnicity, thus generating a valuable reference for future clinical and laboratory studies.
目的
根据临床和实验室标准协会（CLSI）C28 - A3指南，确定中国汉族成年人群血浆中胃泌素释放肽前体（ProGRP）检测的第95百分位数参考区间（RIs）的上限。
方法
收集578名健康成年人的血浆样本。使用雅培ARCHITECT i2000系统分析仪通过化学发光微粒子免疫分析（CMIA）测定血浆ProGRP值。
结果
血浆ProGRP值不符合高斯分布，因此采用非参数统计方法计算参考区间。血浆ProGRP水平随年龄显著升高，因此确定了年龄相关的参考区间。年轻成年人（18 - 50岁）血浆ProGRP第95百分位数参考区间的上限为≤57.26 pg/mL，老年成年人（>50岁）为≤81.42 pg/mL。
结论
通过CMIA，我们建立了中国汉族健康成年人血浆ProGRP不同的年龄相关参考区间，从而为未来的临床和实验室研究提供了有价值的参考。
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