Laratta Cheryl R, van Eeden Stephan
Department of Medicine, University of Alberta, Edmonton, AB, Canada ; UBC James Hogg Research Center, Institute for Heart and Lung Health, University of British Columbia, Canada.
UBC James Hogg Research Center, Institute for Heart and Lung Health, University of British Columbia, Canada ; Respiratory Division, Department of Medicine, St. Paul's Hospital, Vancouver, BC, Canada.
Biomed Res Int. 2014;2014:528789. doi: 10.1155/2014/528789. Epub 2014 Mar 2.
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease resulting from exposure to cigarette smoke, noxious gases, particulate matter, and air pollutants. COPD is exacerbated by acute inflammatory insults such as lung infections (viral and bacterial) and air pollutants which further accelerate the steady decline in lung function. The chronic inflammatory process in the lung contributes to the extrapulmonary manifestations of COPD which are predominantly cardiovascular in nature. Here we review the significant burden of cardiovascular disease in COPD and discuss the clinical and pathological links between acute exacerbations of COPD and cardiovascular disease.
慢性阻塞性肺疾病（COPD）是一种慢性进行性肺部疾病，由接触香烟烟雾、有害气体、颗粒物和空气污染物引起。肺部感染（病毒和细菌）及空气污染物等急性炎症损伤会加重COPD，进一步加速肺功能的持续下降。肺部的慢性炎症过程导致了COPD的肺外表现，这些表现主要为心血管方面的。在此，我们综述了COPD中心血管疾病的重大负担，并讨论了COPD急性加重与心血管疾病之间的临床和病理联系。
