CuBr 促进的 1-炔烃与乙二醛衍生物的形式氢酰化反应：1,2-二羰基-3-烯的意外合成。
CuBr-promoted formal hydroacylation of 1-alkynes with glyoxal derivatives: an unexpected synthesis of 1,2-dicarbonyl-3-enes.
机构信息
Department of Chemistry and Chemical Engineering, Inner Mongolia University , Hohhot 010021, People's Republic of China.
出版信息
J Org Chem. 2014 May 2;79(9):4137-41. doi: 10.1021/jo500199v. Epub 2014 Apr 21.
PMID:24724722
Abstract
An efficient and concise protocol has been developed for the highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives by a copper-promoted reaction of 1-alkynes with α-carbonyl aldehydes in the presence of morpholine. The products obtained are believed as the formal hydroacylation of the triple bond.
摘要
已开发出一种高效简洁的方法，通过铜促进的 1-炔烃与α-羰基醛在吗啉存在下的反应，立体选择性地合成 E-1,2-二羰基-3-烯衍生物。所得产物被认为是三键的形式氢酰化。
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