犬 PVR L4（神经型黏附分子-4）的 V 结构域介导了犬瘟热病毒的进入和病毒的细胞间传播。
The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread.
机构信息
The Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5; IWK Health Centre, Canadian Center for Vaccinology, Goldbloom Pavilion, Halifax, Nova Scotia, Canada B3H 1X5.
The Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5; IWK Health Centre, Canadian Center for Vaccinology, Goldbloom Pavilion, Halifax, Nova Scotia, Canada B3H 1X5; The Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
出版信息
Virology. 2014 Apr;454-455:109-17. doi: 10.1016/j.virol.2014.02.014. Epub 2014 Feb 28.
The entry of canine distemper virus (CDV) is a multistep process that involves the attachment of CDV hemagglutinin (H) to its cellular receptor, followed by fusion between virus and cell membranes. Our laboratory recently identified PVRL4 (nectin-4) to be the epithelial receptor for measles and canine distemper viruses. In this study, we demonstrate that the V domain of PVRL4 is critical for CDV entry and virus cell-to-cell spread. Furthermore, four key amino acid residues within the V domain of dog PVRL4 and two within the CDV hemagglutinin were shown to be essential for receptor-mediated virus entry.
犬瘟热病毒（CDV）的进入是一个多步骤的过程，涉及到 CDV 血凝素（H）与其细胞受体的附着，然后是病毒和细胞膜之间的融合。我们实验室最近确定 PVRL4（神经节苷脂 4）是麻疹和犬瘟热病毒的上皮受体。在这项研究中，我们证明了 PVRL4 的 V 结构域对于 CDV 的进入和病毒的细胞间传播至关重要。此外，狗 PVRL4 的 V 结构域中的四个关键氨基酸残基和 CDV 血凝素中的两个氨基酸残基对于受体介导的病毒进入是必不可少的。
Zotero 插件