Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
Centre de Primatologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
Virology. 2014 Apr;454-455:184-96. doi: 10.1016/j.virol.2014.02.019. Epub 2014 Mar 7.
Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4(+) and CD8(+) T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4(+) and CD8(+) T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.
山魈自然感染猴 T 细胞白血病病毒 1 型（STLV-1）和猴免疫缺陷病毒（SIV）mnd。在人类中，人类免疫缺陷病毒（HIV）和人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）的双重感染可能会使他们的临床结果恶化。我们评估了山魈中合并感染对病毒载量、T 细胞亚群变化和临床结果的影响。与感染动物相比，感染 SIV 的山魈的 SIV 病毒载量更高，而感染 STLV-1 的山魈的 STLV-1 前病毒载量则更高。与单感染组相比，双重感染的山魈的 CD4+T 细胞计数显著降低，幼稚 CD8+T 细胞比例降低，中央记忆细胞比例升高。与其他组相比，来自 SIV 感染动物的 CD4+和 CD8+T 细胞的 Ki67 百分比较低。感染 SIV 的猴子的激活 CD4+和 CD8+T 细胞的百分比更高。两名免疫激活和 STLV 前病毒克隆整合水平较高的合并感染山魈出现了非人类灵长类动物中罕见的病理表现（感染性皮炎和全身性疥疮）。
