Kim Joong-Seok, Kim Su-Young, Choi Jong-Young, Kim Hee-Tae, Oh Yoon-Sang
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 505, Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea.
Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
J Clin Neurosci. 2014 Aug;21(8):1460-2. doi: 10.1016/j.jocn.2013.10.036. Epub 2014 Jan 30.
Orthotopic liver transplantation (OLT) is the sole etiological treatment for Wilson disease (WD), but several neurological complications after OLT have been reported. We report a WD patient who developed a unilateral wing-beating tremor 6years after OLT. New neurological symptoms develop immediately after OLT in most cases. In our patient, the onset of extrapyramidal symptoms was at a prolonged interval after OLT. To our knowledge this is the first patient with delayed extrapyramidal symptoms after OLT in WD where the pathophysiology of these late extrapyramidal symptoms is still unknown.
原位肝移植（OLT）是威尔逊病（WD）唯一的病因治疗方法，但已有报道称OLT后会出现多种神经并发症。我们报告了1例WD患者，在OLT术后6年出现单侧翼状震颤。大多数情况下，OLT后会立即出现新的神经症状。在我们的患者中，锥体外系症状在OLT后较长时间才出现。据我们所知，这是首例WD患者在OLT后出现延迟性锥体外系症状，这些晚期锥体外系症状的病理生理学仍不清楚。
