Ersen Ayca, Unlu Mehtat S, Akman Tulay, Sagol Ozgul, Oztop Ilhan, Atila Koray, Bora Seymen, Ellidokuz Huyla, Sarioglu Sulen
Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey.
Dokuz Eylul University, Faculty of Medicine, Pathology Department, Turkey.
Pathol Res Pract. 2014 Sep;210(9):565-70. doi: 10.1016/j.prp.2014.03.006. Epub 2014 Mar 27.
We performed this study to examine the prevalence of tumor deposits (TD) in gastric adenocarcinomas (GACa), and the relevance of their presence, size and type to clinical outcome. Ninety-six patients, histopathologically diagnosed as GACa following a total/subtotal gastrectomy were included, and clinicopathologic data were recorded. Due to the statistical analysis, the majority of TD(+) cases were of intestinal type and showed vascular invasion. In these cases, the incidence of local recurrence was significantly higher. The majority of GACa of intestinal type with TD were of high grade and showed vascular invasion. Recurrence and death were more commonly encountered among them. The recurrence-free survival (RFS) was significantly shorter in patients with TDs, which was also confirmed by multivariate analysis, and there was a significant difference between both RFS and overall survival of TD(+) and TD(-) cases of intestinal type GACa. In conclusion, in this study, we demonstrate that TDs are not infrequently observed in GACa, they are more commonly associated with the intestinal type and vascular invasive gastric cancers. Our study shows the prognostic impact of TDs, especially regarding the RFS. Therefore, the documentation of TDs might be considered for prospective studies, especially for the intestinal type GACa, a shortcoming of this study.
我们开展这项研究以检测胃腺癌（GACa）中肿瘤沉积物（TD）的发生率，以及其存在、大小和类型与临床结局的相关性。纳入了96例经组织病理学诊断为GACa并行全胃/次全胃切除的患者，并记录临床病理数据。经统计分析，大多数TD（+）病例为肠型且有血管侵犯。在这些病例中，局部复发的发生率显著更高。大多数伴有TD的肠型GACa为高级别且有血管侵犯。复发和死亡在其中更常见。TD患者的无复发生存期（RFS）显著更短，多因素分析也证实了这一点，并且肠型GACa的TD（+）和TD（-）病例在RFS和总生存期方面均存在显著差异。总之，在本研究中，我们证明TD在GACa中并非罕见，它们更常与肠型和血管侵犯性胃癌相关。我们的研究显示了TD的预后影响，尤其是对RFS而言。因此，对于前瞻性研究，特别是针对肠型GACa（本研究的一个不足之处），或许应考虑记录TD。
