Adriaens Antita, Polis Ingeborgh, Vermeire Simon, Waelbers Tim, Croubels Siska, Duchateau Luc, Van Dorpe Sylvia, Eersels Jos, De Spiegeleer Bart, Peremans Kathelijne
Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Eur Neuropsychopharmacol. 2014 Jul;24(7):1133-8. doi: 10.1016/j.euroneuro.2014.03.004. Epub 2014 Mar 26.
Down-stream neuronal alterations, including changes in the 5-HT-2A receptor system, play an important role in the etiology and treatment of depression. The present study examined the effect of prolonged opioid treatment on cerebral 5-HT2A receptors. Cerebral 5-HT2A receptor availability was estimated in seven healthy five-year-old female neutered Beagle dogs pre and post 10-day morphine treatment (oral sustained release morphine 20mg twice daily for 10 days) with (123)I-R-91150, a 5-HT2A selective radioligand, and SPECT. 5-HT2A receptor binding indices (BI) for the frontal, parietal, temporal and occipital cortex and the subcortical region were calculated. Statistical analysis was performed using a linear mixed-effect model with treatment as fixed effect and dog as random effect. Morphine treatment significantly (P≤0.05) lowered 5-HT2A BIs in the right and left frontal cortex, the right and left temporal cortex, the right and left parietal cortex, and the subcortical region. The decreased cerebral 5-HT2A receptor availability following prolonged morphine exposure provides further evidence for an interaction between the opioid and serotonergic system.
包括5-羟色胺-2A受体系统变化在内的下游神经元改变在抑郁症的病因学和治疗中起着重要作用。本研究检测了长期阿片类药物治疗对大脑5-羟色胺2A受体的影响。使用5-羟色胺2A选择性放射性配体(123)I-R-91150和单光子发射计算机断层扫描(SPECT)，对7只健康的5岁雌性绝育比格犬在10天吗啡治疗（口服缓释吗啡20mg，每日两次，共10天）前后的大脑5-羟色胺2A受体可利用性进行了评估。计算了额叶、顶叶、颞叶、枕叶皮质以及皮质下区域的5-羟色胺2A受体结合指数(BI)。采用线性混合效应模型进行统计分析，将治疗作为固定效应，将犬作为随机效应。吗啡治疗显著(P≤0.05)降低了左右额叶皮质、左右颞叶皮质、左右顶叶皮质以及皮质下区域的5-羟色胺2A结合指数。长期吗啡暴露后大脑5-羟色胺2A受体可利用性降低，为阿片类药物和5-羟色胺能系统之间的相互作用提供了进一步的证据。
