发现并研究新型四氢吡咯并[3,4-c]吡唑作为 N 型钙通道抑制剂。
Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.
机构信息
Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.
出版信息
Bioorg Med Chem Lett. 2014 May 1;24(9):2053-6. doi: 10.1016/j.bmcl.2014.03.062. Epub 2014 Mar 27.
PMID:24726802
Abstract
A novel series of substituted tetrahydropyrrolo[3,4-c]pyrazoles were investigated as blockers of the N-type calcium channel (Cav2.2 channels), a chronic pain target.
摘要
研究了一系列新型取代的四氢吡咯并[3,4-c]吡唑作为 N 型钙通道（Cav2.2 通道）的阻断剂，Cav2.2 通道是慢性疼痛的靶点。
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