硝酸甘油在心肺复苏期间的作用。

The effects of nitroglycerin during cardiopulmonary resuscitation.

机构信息

MSc Program Cardiopulmonary Resuscitation, University of Athens, Medical School, Greece, 75 Mikras Asias Street, 11527 Athens, Greece.

出版信息

Eur J Pharmacol. 2014 Jul 5;734:42-9. doi: 10.1016/j.ejphar.2014.04.002. Epub 2014 Apr 13.

DOI:10.1016/j.ejphar.2014.04.002

PMID:24726850

Abstract

The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocardial and cerebral organ blood flow. Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow. Several studies suggest that combined use of nitroglycerin with vasopressors during resuscitation, is associated with increased rates of resuscitation and improved post-resuscitation outcome. This article reviews the effects of nitroglycerin during cardiopulmonary resuscitation and postresuscitation period, as well as the beneficial outcomes of a combination regimen consisting of a vasopressor and a vasodilator, such as nitroglycerin.

摘要

院内心脏骤停和院外心脏骤停的预后仍然不佳。血管加压素用于增加冠状动脉灌注压，从而在心肺复苏期间促进自主循环的恢复。然而，它们与许多潜在的不良反应有关，并且可能会减少心内膜和脑器官的血流。硝酸甘油具有有利的血流动力学特性，可促进正向血流。多项研究表明，在复苏过程中联合使用硝酸甘油和血管加压素与复苏成功率的提高和复苏后结局的改善有关。本文综述了硝酸甘油在心肺复苏期间和复苏后期间的作用，以及血管加压素和血管扩张剂（如硝酸甘油）联合方案的有益结果。