Institute of Neurobiology, Acad. G. Bonchev Str., Bl. 23, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria.
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Brain Res Bull. 2014 May;104:27-35. doi: 10.1016/j.brainresbull.2014.04.001. Epub 2014 Apr 13.
The influence of pre- and postnatal caffeine treatment on brain excitability during development and adulthood is reviewed. Pre- and postnatal exposure to caffeine induces sex- and age-specific long-term neurochemical alterations in the brain and the behavior of rodents. Because adenosine neuromodulation is closely related to the regulation of brain excitability the increased expression in adenosine receptor system due to neonatal caffeine treatment should cause transient and permanent changes in seizure susceptibility. So far, findings have been focused on primarily developmental changes of the brain adenosine modulatory system and have demonstrated that the alterations are not restricted to a single brain region. Neurobehavioral changes and the anticonvulsant effect of early caffeine exposure are dependent on the caffeine dose, developmental stage of exposure and age of testing. Although outcomes of caffeine treatment are still a matter of debate, our review raise questions concerning the impact of early caffeine treatment on regulation of seizure susceptibility during development and adulthood.
本文综述了产前和产后咖啡因处理对发育和成年期大脑兴奋性的影响。产前和产后暴露于咖啡因会导致啮齿动物的大脑和行为出现性别和年龄特异性的长期神经化学改变。由于腺苷神经调制与大脑兴奋性的调节密切相关，由于新生期咖啡因处理导致的腺苷受体系统表达增加，应该会导致癫痫易感性的短暂和永久性改变。到目前为止，研究结果主要集中在大脑腺苷调节系统的发育变化上，并且已经证明这些改变不仅限于单个脑区。神经行为的变化和早期咖啡因暴露的抗惊厥作用取决于咖啡因剂量、暴露的发育阶段和测试的年龄。尽管咖啡因治疗的结果仍存在争议，但我们的综述提出了关于早期咖啡因处理对发育和成年期癫痫易感性调节的影响的问题。
