Conti Fabiana Mendes, Hibner Sergio, Costa Thiago Henrique, Dezan Marcia Regina, Aravechia Maria Giselda, Pereira Ricardo Antonio D Almeida, Kondo Andrea Tiemi, D'Amico Élbio Antônio, Mota Mariza, Kutner José Mauro
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2014 Jan-Mar;12(1):96-9. doi: 10.1590/s1679-45082014rc2729.
Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia in subsequent pregnancies. This article reports a case of neonatal alloimmune thrombocytopenia in the second pregnancy affected and discusses diagnosis, management and the clinical importance of this disease.
新生儿同种免疫性血小板减少症是一种严重疾病，母亲会产生针对从父亲遗传而来的胎儿血小板抗原的抗体；它仍然是一种诊断不足的疾病。这种疾病被认为是胎儿和新生儿RhD溶血病的血小板对应物，但在新生儿同种免疫性血小板减少症中，第一个孩子会受到胎儿和/或新生儿血小板减少症的影响。存在颅内出血和严重神经功能障碍的重大风险，在后续妊娠中血小板减少症有更早且更严重的趋势。本文报告了一例二胎受影响的新生儿同种免疫性血小板减少症病例，并讨论了该疾病的诊断、管理及临床重要性。
