聚（rI.rC）和阿司匹林对细胞色素P450依赖性药物生物转化的抑制作用。

Depression of cytochrome P450-dependent drug biotransformation by poly(rI.rC) and aspirin.

作者信息

Jagota S K

机构信息

Department of Biochemistry, Panjab University, Chandigarh.

出版信息

Biochem Med Metab Biol. 1989 Jun;41(3):212-6. doi: 10.1016/0885-4505(89)90028-5.

DOI:10.1016/0885-4505(89)90028-5

PMID:2472829

Abstract

The inhibition of hepatic microsomal cytochrome P450 and cytochrome b5 levels by poly(rI.rC) and aspirin in vitro was studied in male Swiss mice. Poly(rI.rC) (10 mg/kg) decreases cytochrome P450 to a level of 61% and cytochrome b5 to 31%, while the activity of aminopyrine demethylase was decreased to 66%. Aspirin (200 mg/kg) decreased the level of cytochrome P450 and cytochrome b5 to 45 and 23%, respectively. Further studies on the effect of poly(rI.rC) showed that this decrease in the levels of cytochromes was mainly due to alteration in the protein synthesis of these hemoproteins.

摘要

在雄性瑞士小鼠中研究了聚肌苷酸-聚胞苷酸（poly(rI.rC)）和阿司匹林在体外对肝微粒体细胞色素P450和细胞色素b5水平的抑制作用。聚肌苷酸-聚胞苷酸（10毫克/千克）使细胞色素P450水平降至61%，细胞色素b5降至31%，而氨基比林脱甲基酶的活性降至66%。阿司匹林（200毫克/千克）分别使细胞色素P450和细胞色素b5水平降至45%和23%。对聚肌苷酸-聚胞苷酸作用的进一步研究表明，细胞色素水平的这种降低主要是由于这些血红素蛋白的蛋白质合成发生了改变。