体外培养的艾氏腹水瘤细胞中葡萄糖载体数量与细胞内磷酸核糖二磷酸水平的相互关系
Interrelationship of number of glucose carriers and intracellular phosphoribosyl diphosphate level of Ehrlich ascites tumor cells in vitro.
作者信息
Choy Y M, Lam W P, Fung K P
机构信息
Department of Biochemistry, Chinese University of Hong Kong, Shatin.
出版信息
Cancer Biochem Biophys. 1988 Nov;10(2):141-7.
The intracellular phosphoribosyl diphosphate (prpp) levels of Ehrlich ascites tumor cells increased during glucose supplementation and decreased during glucose deprivation, while the numbers of glucose carriers as determined by glucose-reversible cytochalasin-B binding changed in an opposite manner relating to the extracellular glucose concentrations and the intracellular prpp levels of Ehrlich ascites tumor cells in vitro. Incubation of cells with hypoxanthine or 2,4-dinitrophenol lowered the intracellular prpp levels and resulted in an increase in numbers of glucose carriers.
在补充葡萄糖期间，艾氏腹水癌细胞内的磷酸核糖焦磷酸（prpp）水平升高，而在葡萄糖缺乏期间则降低，同时，通过葡萄糖可逆性细胞松弛素B结合测定的葡萄糖载体数量与细胞外葡萄糖浓度和体外艾氏腹水癌细胞内的prpp水平呈相反变化。用次黄嘌呤或2,4-二硝基苯酚孵育细胞会降低细胞内prpp水平，并导致葡萄糖载体数量增加。
Zotero 插件