Dehsorkhi Ashkan, Castelletto Valeria, Hamley Ian W
Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
J Pept Sci. 2014 Jul;20(7):453-67. doi: 10.1002/psc.2633. Epub 2014 Apr 13.
The self-assembly of several classes of amphiphilic peptides is reviewed, and selected applications are discussed. We discuss recent work on the self-assembly of lipopeptides, surfactant-like peptides and amyloid peptides derived from the amyloid-β peptide. The influence of environmental variables such as pH and temperature on aggregate nanostructure is discussed. Enzyme-induced remodelling due to peptide cleavage and nanostructure control through photocleavage or photo-cross-linking are also considered. Lastly, selected applications of amphiphilic peptides in biomedicine and materials science are outlined.
本文综述了几类两亲性肽的自组装，并讨论了其特定应用。我们探讨了脂肽、类表面活性剂肽以及源自β-淀粉样肽的淀粉样肽自组装方面的最新研究工作。讨论了诸如pH值和温度等环境变量对聚集体纳米结构的影响。还考虑了由于肽裂解引起的酶促重塑以及通过光裂解或光交联进行的纳米结构控制。最后，概述了两亲性肽在生物医学和材料科学中的特定应用。
