Carney L G, Kiely P M, Brennan N A, Crewther S G, Nathan J
Department of Optometry, University of Melbourne, Australia.
Cornea. 1989 Sep;8(3):182-7.
Soft extended wear contact lenses were designed for and fitted to 12 eyes of 11 infant semiwild cynomolgus monkeys. The lenses were satisfactorily worn over observation periods of up to 465 days, the longest continuous period of lens wear being 69 days. However, some of the corneas were subject to a pattern of complications analogous to that in human contact lens wear. Nine eyes showed adverse responses, and of these, the ocular complications were severe enough in four cases to cause abandonment of lens wear. The most remarkable feature of the complications was the rapid recovery of severe reactions to near normality in less than 24 h, indicating an impressive ability of the cornea to tolerate and survive insult. Another feature was the recurrent nature of mild complications in certain monkeys despite apparent resolution from previous episodes. There appeared to be no correlation between duration of lens wear and appearance of the first or recurrent episodes of corneal infiltration and vascularization.
软性长戴型隐形眼镜专为11只幼年半野生食蟹猴的12只眼睛设计并佩戴。在长达465天的观察期内，这些隐形眼镜佩戴情况良好，最长连续佩戴时间为69天。然而，部分角膜出现了类似于人类佩戴隐形眼镜时的一系列并发症。9只眼睛出现了不良反应，其中4例眼部并发症严重到不得不停止佩戴隐形眼镜。并发症最显著的特点是严重反应在不到24小时内迅速恢复到接近正常状态，这表明角膜具有令人印象深刻的耐受和抵御损伤的能力。另一个特点是，尽管某些猴子之前的轻微并发症似乎已经消退，但仍会复发。隐形眼镜佩戴时间与角膜浸润和血管化首次发作或复发之间似乎没有关联。
