Jung Michael E, Trzoss Michael, Tsay James M, Weiss Shimon
Department of Chemistry and Biochemistry, California NanoSystems Institute, and Department of Physiology, University of California at Los Angeles, Los Angeles, CA 90095-1569, USA.
Synthesis (Stuttg). 2013 Sep 1;45(17):2426-2430. doi: 10.1055/s-0033-1339340.
We describe a new class of ligands for semiconductor nanoparticles (quantum dots = QDs), which bind well and allow for their facile dissolution in aqueous solution. As a proof of principle, we have designed and synthesized a novel bis(phosphine)-modified peptide (BPMP) and shown that it has the ability to solubilize quantum dots in aqueous media. We further showed that the corresponding phosphine oxide derivatives of these new ligands are less good at solubilizing the quantum dots. These new bis(phosphine)-modified peptide ligands are easy to prepare and may well replace thiol-containing binding sequences in functionalized peptides for quantum dot coating, potentially resulting in quantum dots with higher quantum yields.
我们描述了一类用于半导体纳米颗粒（量子点=QDs）的新型配体，它们能很好地结合并使其易于溶解在水溶液中。作为原理验证，我们设计并合成了一种新型双（膦）修饰肽（BPMP），并表明它有能力在水性介质中溶解量子点。我们进一步表明，这些新配体的相应氧化膦衍生物在溶解量子点方面效果较差。这些新型双（膦）修饰肽配体易于制备，很可能会取代功能化肽中用于量子点包覆的含硫醇结合序列，从而可能得到具有更高量子产率的量子点。
