Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA). - Suppr | 超能文献

Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA).

作者信息

Lowy M T, Nash J F, Meltzer H Y

机构信息

Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Eur J Pharmacol. 1989 Apr 12;163(1):157-61. doi: 10.1016/0014-2999(89)90411-1.

DOI:10.1016/0014-2999(89)90411-1

Abstract

A single 20 mg/kg dose of 3,4-methylenedioxymethamphetamine (MDMA) administered to rats markedly decreased serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in hippocampus, frontal cortex and striatum seven days following injection. MDMA also significantly decreased type II glucocorticoid receptor levels in the striatum, but not in hippocampus or frontal cortex. Since no difference in basal serum corticosterone levels was observed between the two groups, MDMA may decrease striatal type II glucocorticoid receptors via a corticosterone-independent mechanism.

摘要

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