3,4-亚甲基二氧甲基苯丙胺（摇头丸）对大鼠纹状体II型糖皮质激素受体的选择性降低作用

Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA).

作者信息

Lowy M T, Nash J F, Meltzer H Y

机构信息

Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Eur J Pharmacol. 1989 Apr 12;163(1):157-61. doi: 10.1016/0014-2999(89)90411-1.

DOI:10.1016/0014-2999(89)90411-1

PMID:2472965

Abstract

A single 20 mg/kg dose of 3,4-methylenedioxymethamphetamine (MDMA) administered to rats markedly decreased serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in hippocampus, frontal cortex and striatum seven days following injection. MDMA also significantly decreased type II glucocorticoid receptor levels in the striatum, but not in hippocampus or frontal cortex. Since no difference in basal serum corticosterone levels was observed between the two groups, MDMA may decrease striatal type II glucocorticoid receptors via a corticosterone-independent mechanism.

摘要

给大鼠单次注射20毫克/千克剂量的3,4-亚甲基二氧甲基苯丙胺（摇头丸）后，在注射七天后，海马体、额叶皮质和纹状体中的血清素（5-羟色胺，5-HT）和5-羟吲哚乙酸（5-HIAA）水平显著降低。摇头丸还显著降低了纹状体中II型糖皮质激素受体的水平，但在海马体或额叶皮质中没有降低。由于两组之间未观察到基础血清皮质酮水平的差异，摇头丸可能通过一种不依赖皮质酮的机制降低纹状体中II型糖皮质激素受体的水平。