Suokas Kimmo, Kampman Olli
Duodecim. 2014;130(5):469-74.
Antibodies directed to the surface structures of nerve cells may cause autoimmune encephalitis. It may cause limbic encephalitis requiring intensive care, or symptoms are restricted to psychosis. This disease may be impossible to distinguish clinically from a functional psychotic illness. Some of the cases are paraneoplastic, i.e. associated with a diagnosed or latent malignant neoplasia, most commonly ovarian teratoma. The first line treatment for autoimmune encephalitis is an immunomodulatory combination therapy with immunoglobulin and methylprednisolone. We recommend screening of the most common NMDAR and VGKC antibodies related to autoimmune encephalitis from patients having developed a new psychosis.
针对神经细胞表面结构的抗体可能会引发自身免疫性脑炎。它可能导致需要重症监护的边缘性脑炎，或者症状仅限于精神病。这种疾病在临床上可能无法与功能性精神病性疾病区分开来。一些病例是副肿瘤性的，即与已诊断或潜在的恶性肿瘤相关，最常见的是卵巢畸胎瘤。自身免疫性脑炎的一线治疗是使用免疫球蛋白和甲泼尼龙进行免疫调节联合治疗。我们建议对出现新发精神病的患者筛查与自身免疫性脑炎相关的最常见的NMDAR和VGKC抗体。
