Imenpour H, Ivaldi G P, Brianti A, Pastorino G, Biggi S, Auriati L, Simonassi C
Pathologica. 2013 Dec;105(6):353-6.
We report a rare case of diffuse malignant pleural mesothelioma synchronous with a localized adenocarcinoma of lung in a 68-year old man with a suspicious history of asbestos exposure. Computed tomography revealed a sub-pleural mass in the lower lobe and an irregular dense area of medium lobe of right lung with thickening of pleura encasing the lung parenchyma and homolateral pleural effusion 1 cm thick. The patient underwent surgery and a right medium and lower lobectomy was performed. Upon frozen sections, intraoperative diagnosis was adenocarcinoma with a poorly differentiated component of lung infiltrating the pleura. The postoperative histological definitive diagnosis with an important contribution of immunostaining was synchronous pulmonary adenocarcinoma and pleural diffuse malignant epithelioid mesothelioma.
我们报告了一例罕见病例，一名68岁有石棉接触可疑史的男性，患有弥漫性恶性胸膜间皮瘤，同时伴有局限性肺腺癌。计算机断层扫描显示右下叶有一个胸膜下肿块，右肺中叶有一个不规则的致密区域，胸膜增厚包绕肺实质，同侧胸腔积液厚1厘米。患者接受了手术，进行了右中、下叶切除术。术中冰冻切片诊断为腺癌，伴有肺低分化成分浸润胸膜。术后通过免疫染色的重要辅助进行组织学确诊，结果为同步性肺腺癌和胸膜弥漫性恶性上皮样间皮瘤。
