Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Science & Research Center, Amrita Vishwa Vidyapeetham University, Cochin, Kerala 682041, India.
Curr Drug Deliv. 2014;11(6):687-700. doi: 10.2174/1567201811666140414120002.
Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.
骨髓炎的特征是进行性炎症性骨退化。在慢性骨髓炎的治疗中，有必要切除感染的骨组织，然后植入一种可以局部长时间释放抗生素的抗生素释放生物材料。临床上用于该应用的主要载体是聚甲基丙烯酸甲酯（PMMA）（例如 Septopal 珠）。然而，主要缺点是治疗后需要进行额外的手术来去除珠粒，因为 PMMA 不可生物降解。这就需要可生物降解的载体系统，该系统可以释放抗生素并同时支持清创骨形成。本文综述了已报道的用于局部治疗和预防骨髓炎的可生物降解载体系统。
