Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
J Org Chem. 2014 May 2;79(9):3924-9. doi: 10.1021/jo5003856. Epub 2014 Apr 23.
An asymmetric synthesis of epoxyoxindoles from isatins has been developed by employing chiral sulfur ylides generated in situ from camphor-derived sulfonium salts. This reaction allows an efficient access to enantioenriched spiro-epoxyoxindoles under mild reaction conditions, featuring high yields and excellent enantio- and diastereoselectivities.
一种不对称合成环氧吲哚的方法已由使用手性硫叶立德原位从莰衍生的硫翁盐开发。该反应允许在温和的反应条件下有效地获得对映体富集的螺环环氧吲哚，具有高产率和优异的对映选择性和非对映选择性。
